abstract：AIM:To assess the effect of Schisandra sphenanthera extract (SchE) on the pharmacokinetics of tacrolimus in healthy volunteers. METHODS:Twelve healthy male volunteers were orally treated with SchE, three capsules twice daily for 13 days. Pharmacokinetic investigations of oral tacrolimus administration at 2 mg were per...

journal_title：British journal of clinical pharmacology

authors： Xin HW,Wu XC,Li Q,Yu AR,Zhu M,Shen Y,Su D,Xiong L

更新日期：2007-10-01 00:00:00

abstract：AIMS:Major bleeding complications with low-molecular-weight heparin (LMWH) treatment have been reported both in clinical studies and during postmarketing surveillance. Monitoring of antifactor Xa (anti-Xa) activities is therefore recommended in special populations often predisposed to renal impairment. The PROPHRE.75 s...

journal_title：British journal of clinical pharmacology

authors： Berges A,Laporte S,Epinat M,Zufferey P,Alamartine E,Tranchand B,Decousus H,Mismetti P,PROPHRE.75 Study Group.

更新日期：2007-10-01 00:00:00

abstract：AIMS:To determine whether and to what extent bronchoconstriction affects plasma concentrations of fluticasone and budesonide following inhalation. METHODS:Twenty people with mild asthma inhaled 1000 microg fluticasone (Accuhaler) plus 800 microg budesonide (Turbohaler) on two visits. On one occasion, prior to drug inh...

journal_title：British journal of clinical pharmacology

authors： Mortimer KJ,Tattersfield AE,Tang Y,Wu K,Lewis S,Hochhaus G,Harrison TW

更新日期：2007-10-01 00:00:00

abstract：AIMS:Pravastatin is a 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor, which is widely used both in primary and secondary prevention of coronary heart disease (CHD). Pravastatin is not subject to metabolism by cytochrome P450s, but it is actively transported from blood into target tissues (e.g. hepa...

journal_title：British journal of clinical pharmacology

authors： Zhang W,Chen BL,Ozdemir V,He YJ,Zhou G,Peng DD,Deng S,Xie QY,Xie W,Xu LY,Wang LC,Fan L,Wang A,Zhou HH

更新日期：2007-09-01 00:00:00

abstract：AIMS:Statins have been suggested to prevent haematological malignancies. Several epidemiological studies have evaluated this association, while randomized controlled trials (RCTs) on cardiovascular outcomes have provided relevant data as secondary end-points. Our aim was to examine the strength of this association thro...

journal_title：British journal of clinical pharmacology

authors： Bonovas S,Filioussi K,Tsantes A,Sitaras NM

更新日期：2007-09-01 00:00:00

abstract：AIMS:The protease inhibitor indinavir is characterized by an important interindividual pharmacokinetic variability, which results from the actions of the metabolizing enzymes cytochrome P450 (CYP) 3A and the multidrug efflux pump P-glycoprotein (P-gp), encoded by MDR1. Using a population pharmacokinetic approach, we in...

journal_title：British journal of clinical pharmacology

authors： Solas C,Simon N,Drogoul MP,Quaranta S,Frixon-Marin V,Bourgarel-Rey V,Brunet C,Gastaut JA,Durand A,Lacarelle B,Poizot-Martin I

更新日期：2007-09-01 00:00:00

abstract：AIMS:Venlafaxine may increase the risk of arrhythmia in certain patients. We sought to characterize the cardiovascular effects of venlafaxine overdose in adults. METHODS:A retrospective casenote review of patients admitted to the Royal Infirmary of Edinburgh between January 2000 and June 2006. Haemodynamic and electro...

journal_title：British journal of clinical pharmacology

authors： Howell C,Wilson AD,Waring WS

更新日期：2007-08-01 00:00:00

abstract：AIMS:Flavonoids may affect platelet function by several mechanisms, including antagonism of TxA(2) receptors (TP). These TP are present in many tissues and modulate different signalling cascades. We explored whether flavonoids affect platelet TP signalling, and if they bind to TP expressed in other cell types. METHODS...

journal_title：British journal of clinical pharmacology

authors： Guerrero JA,Navarro-Nuñez L,Lozano ML,Martínez C,Vicente V,Gibbins JM,Rivera J

更新日期：2007-08-01 00:00:00

abstract：AIMS:To characterize the absorption kinetics and bioavailability of an inhaled hydrophilic solute deposited at various sites within the airways. METHODS:Nine healthy nonsmokers received one intravenous, one oropharyngeal and two pulmonary doses of technetium-99 m-labelled diethylene triamine pentaacetic acid ((99m)Tc-...

journal_title：British journal of clinical pharmacology

authors： Bondesson E,Bengtsson T,Nilsson LE,Wollmer P

更新日期：2007-06-01 00:00:00

abstract：WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT:* Therapeutic drug monitoring of serum digoxin concentrations (SDC) is considered useful in enhancing the therapeutic benefits of digoxin and minimizing the incidence of adverse drug reactions. * The quality of requests for SDC has been reported to be generally unsatisfactory. H...

journal_title：British journal of clinical pharmacology

authors： Ellington C,Grgurinovich N,Miners JO,Mangoni AA

更新日期：2007-05-01 00:00:00

abstract：WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT:* The variability in drug metabolism has been recognized as an important factor in the occurrence of adverse effects or lack of therapeutic efficacy. * The metabolism of the third-generation beta(1)-receptor antagonist nebivolol has been shown to be highly dependent on cytochrom...

journal_title：British journal of clinical pharmacology

authors： Lefebvre J,Poirier L,Poirier P,Turgeon J,Lacourciere Y

更新日期：2007-05-01 00:00:00

abstract：AIM:Omalizumab, a humanized IgG monoclonal antibody that binds to human immunoglobulin E (IgE), interrupts the allergic cascade in asthmatic patients. The aim was to compare simultaneously drug exposure and IgE biomarker responses in Japanese and White patient populations. METHODS:An instantaneous equilibrium drug-lig...

journal_title：British journal of clinical pharmacology

authors： Hayashi N,Tsukamoto Y,Sallas WM,Lowe PJ

更新日期：2007-05-01 00:00:00

abstract：UNLABELLED:WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT?: * Two chemically diverse CCK1 receptor antagonists have been shown clinically to inhibit CCK-evoked contraction of human gallbladder [2, 3]. These studies have not examined the relationship between plasma concentration and effect, the latter usually considered to be...

journal_title：British journal of clinical pharmacology

authors： Gerskowitch VP,Hodge J,Hull RA,Shankley NP,Kalindjian SB,McEwen J,Black JW

更新日期：2007-05-01 00:00:00

abstract：AIMS:To compare single- and multiple-dose duloxetine pharmacokinetics between healthy Japanese and Caucasians. METHODS:Twenty-four subjects of each race were given single oral doses of duloxetine (20, 40 and 60 mg) in a randomized, double-blind study. Another 20 subjects of each race received 20, 40 mg or placebo (2 :...

journal_title：British journal of clinical pharmacology

authors： Chan C,Yeo KP,Pan AX,Lim M,Knadler MP,Small DS

更新日期：2007-03-01 00:00:00

abstract：AIMS:To investigate the effect of multiple dosing with montelukast, a selective leukotriene-receptor antagonist, on the pharmacokinetics of rosiglitazone, a CYP2C8 substrate, in humans. METHODS:A two-period, randomized crossover study was conducted in 10 healthy subjects. After administration of oral doses of placebo ...

journal_title：British journal of clinical pharmacology

authors： Kim KA,Park PW,Kim KR,Park JY

更新日期：2007-03-01 00:00:00

abstract：AIM:In short-term studies, hormonal contraceptives (HC) have been suggested to induce a rise in blood pressure (BP) and urinary albumin excretion (UAE), while the effect of HC in renal function (GFR) is still under debate. Data on long-term and withdrawal effects of HC use on these outcomes are, however, not available....

journal_title：British journal of clinical pharmacology

authors： Atthobari J,Gansevoort RT,Visser ST,de Jong PE,de Jong-van den Berg LT,PREVEND Study Group.

更新日期：2007-02-01 00:00:00

abstract：AIMS:QTc interval-prolonging drugs have been linked to cardiac arrhythmias, cardiac arrest and sudden death. In this study we aimed to quantify the risk of cardiac arrest associated with the use of non-antiarrhythmic QTc-prolonging drugs in an academic hospital setting. METHODS:We performed a case-control study in whi...

journal_title：British journal of clinical pharmacology

authors： De Bruin ML,Langendijk PN,Koopmans RP,Wilde AA,Leufkens HG,Hoes AW

更新日期：2007-02-01 00:00:00

abstract：AIMS:Although cysteamine was first used in the treatment of cystinosis in 1976 and approved by the FDA as cysteamine bitartrate (Cystagon) in 1994, surprisingly little pharmacological data are available for this compound. Cysteamine and its related drugs are currently being evaluated for the treatment of Huntington's a...

journal_title：British journal of clinical pharmacology

authors： Fidler MC,Barshop BA,Gangoiti JA,Deutsch R,Martin M,Schneider JA,Dohil R

更新日期：2007-01-01 00:00:00

abstract：AIMS:The aim of this study was to investigate the impact of new insights and revised guidelines on initial and follow-up treatment with antihyperglycaemic drugs over the period 1998-2003. METHODS:The InterAction Database (IADB), which contains pharmacy dispensing data from 53 community pharmacies in the Northern and E...

journal_title：British journal of clinical pharmacology

authors： Lub R,Denig P,van den Berg PB,Hoogenberg K,de Jong-van den Berg LT

更新日期：2006-12-01 00:00:00

abstract：AIM:To evaluate a context-learning pharmacotherapy programme for approximately 750 2nd, 3rd and 4th year preclinical medical students with respect to mastering cognitive pharmacotherapeutic skills, i.e. choosing a (drug) treatment and determining patient information. METHODS:The context-learning pharmacotherapy progra...

journal_title：British journal of clinical pharmacology

authors： Vollebregt JA,van Oldenrijk J,Kox D,van Galen SR,Sturm B,Metz JC,Richir MC,de Haan M,Hugtenburg JG,de Vries TP

更新日期：2006-12-01 00:00:00

abstract：AIMS:To describe the pharmacokinetic-pharmacodynamic (PK-PD) characteristics of the direct thrombin inhibitor dabigatran in hip replacement patients by assessing coagulation parameters activated partial thromboplastin time (aPTT) and ecarin clotting time (ECT), interindividual variability and factors affecting PD respo...

journal_title：British journal of clinical pharmacology

authors： Liesenfeld KH,Schäfer HG,Trocóniz IF,Tillmann C,Eriksson BI,Stangier J

更新日期：2006-11-01 00:00:00

abstract：AIMS:Thiazolidinediones (TZDs) not only enhance cellular glucose transport but are reported to have potent anti-inflammatory effects. These effects may play an important role in the insulin sensitizing mechanism, and possibly precede the effects on parameters of glucoregulation. We sought to investigate whether these a...

journal_title：British journal of clinical pharmacology

authors： van Doorn M,Kemme M,Ouwens M,van Hoogdalem EJ,Jones R,Romijn H,de Kam M,Schoemaker R,Burggraaf K,Cohen A

更新日期：2006-10-01 00:00:00

abstract：AIMS:A recent case report had suggested a citrus soft drink (Sun Drop) may have caused clinically relevant elevations in ciclosporin levels through a grapefruit juice-like mechanism via inactivation of intestinal cytochrome P450 3A4 (CYP3A4). This study was conducted to investigate the effect of grapefruit juice and ci...

journal_title：British journal of clinical pharmacology

authors： Schwarz UI,Johnston PE,Bailey DG,Kim RB,Mayo G,Milstone A

更新日期：2006-10-01 00:00:00

abstract：AIMS:This study assessed the effects of the CYP3A inhibitors lopinavir/ritonavir (LPV/r) on the steady-state pharmacokinetics (PK) of aplaviroc (APL), a CYP3A4 substrate, in healthy subjects. METHODS:In Part 1, APL PK was determined in eight subjects who received a single oral 50-mg APL test dose with/without a single...

journal_title：British journal of clinical pharmacology

authors： Adkison KK,Shachoy-Clark A,Fang L,Lou Y,Otto VR,Berrey MM,Piscitelli SC

更新日期：2006-09-01 00:00:00

abstract：AIMS:To assess the antihistaminic activity of levocetirizine and fexofenadine 2 h and 24 h after drug administration using facial thermography and to compare the results with those using well-established parameters of antihistaminic activity in the nose and skin. METHODS:This was a randomized, double-blind, three-trea...

journal_title：British journal of clinical pharmacology

authors： Larbig M,Burtin B,Martin L,Stamm H,Luettig B,Hohlfeld JM,Krug N

更新日期：2006-08-01 00:00:00

abstract：AIMS:Carbamazepine (CBZ) is an inducer of cytochrome P450 enzymes, which have been implicated in many drug interactions. However, for immunosuppressant and anti-HIV drugs, whose main site of action is the lymphocyte, induction of P-glycoprotein (Pgp) may also be important. In this study, we have investigated whether CB...

journal_title：British journal of clinical pharmacology

authors： Owen A,Goldring C,Morgan P,Park BK,Pirmohamed M

更新日期：2006-08-01 00:00:00

abstract：AIMS:To characterize determinants of the elimination of methotrexate (MTX) and 7-hydroxy-methotrexate (7-OH-MTX) in patients receiving high-dose MTX therapy (HDMTX). METHODS:24 and 48-h blood samples from 76 patients receiving HDMTX (dose range 300 mg m-2 to 12 g m-2) were analysed, and concentration-time data were su...

journal_title：British journal of clinical pharmacology

authors： Joerger M,Huitema AD,van den Bongard HJ,Baas P,Schornagel JH,Schellens JH,Beijnen JH

更新日期：2006-07-01 00:00:00

abstract：:The burgeoning problem of malaria in the developing world and the relentless march of drug resistance demand that we continue to seek new chemotherapeutic strategies. Given the enormous expense of developing and marketing new chemical entities, we often rely on an increased understanding of the pharmacology of older d...

journal_title：British journal of clinical pharmacology

authors： Edwards G,Biagini GA

更新日期：2006-06-01 00:00:00

abstract：:Coumarins are the mainstay of oral anticoagulation for the treatment and prophylaxis of thromboembolic disorders. They have a narrow therapeutic index and regular monitoring is therefore required to avoid serious adverse effects. There is wide interindividual variability in dosage requirements, which makes anticoagula...

journal_title：British journal of clinical pharmacology

authors： Kamali F,Pirmohamed M

更新日期：2006-06-01 00:00:00

abstract：AIMS:To characterize potential mechanism-based inactivation (MBI) of major human drug-metabolizing cytochromes P450 (CYP) by monoamine oxidase (MAO) inhibitors, including the antitubercular drug isoniazid. METHODS:Human liver microsomal CYP1A2, CYP2C9, CYP2C19, CYP2D6 and CYP3A activities were investigated following c...

journal_title：British journal of clinical pharmacology

authors： Polasek TM,Elliot DJ,Somogyi AA,Gillam EM,Lewis BC,Miners JO

更新日期：2006-05-01 00:00:00

abstract：AIMS:Spirometry, plethysmography and impulse oscillometry (IOS) measure different aspects of lung function. These methods have not been compared for their ability to assess long- and short-acting anticholinergic agents. We therefore performed a double-blind, placebo-controlled, four-way cross-over study in 30 healthy s...

journal_title：British journal of clinical pharmacology

authors： Singh D,Tal-Singer R,Faiferman I,Lasenby S,Henderson A,Wessels D,Goosen A,Dallow N,Vessey R,Goldman M

更新日期：2006-04-01 00:00:00

abstract：AIMS:The Transdermal Delivery System (TDS) is a liquid formulation that can be applied to the skin via a metered pump spray to deliver drug to the systemic circulation. The aims of this study were to assess the ability of the TDS preparation to deliver testosterone systemically, and to characterize the pharmacokinetic ...

journal_title：British journal of clinical pharmacology

authors： Chik Z,Johnston A,Tucker AT,Chew SL,Michaels L,Alam CA

更新日期：2006-03-01 00:00:00

abstract：AIMS:To determine whether preclinical medical students are able to learn therapeutic problem solving simultaneously with gaining knowledge of pharmacology. METHODS:A randomized controlled pre/post-test study among 85 3rd year preclinical medical students from two medical faculties in Amsterdam. In addition to the norm...

journal_title：British journal of clinical pharmacology

authors： Vollebregt JA,Metz JC,de Haan M,Richir MC,Hugtenburg JG,de Vries TP

更新日期：2006-03-01 00:00:00

abstract：AIMS:To compare the disposition of fluoxetine and norfluoxetine enantiomers in the mother, foetus and infant. METHODS:Blood from pregnant women taking fluoxetine (n = 9), during pregnancy was sampled in the third trimester and at delivery (maternal and cord venous blood), and from the infants 48 h after delivery. The ...

journal_title：British journal of clinical pharmacology

authors： Kim J,Riggs KW,Misri S,Kent N,Oberlander TF,Grunau RE,Fitzgerald C,Rurak DW

更新日期：2006-02-01 00:00:00

abstract：AIM:Identify and quantify factors describing variability of amikacin clearance in preterm neonates at birth. METHODS:Population pharmacokinetics of amikacin were estimated in a cohort of 205 extreme preterm neonates [post conception age (PCA) 27.8, SD 1.8, range 24-30 weeks; weight 1.07, SD 0.34, range 0.45-1.98 kg, p...

journal_title：British journal of clinical pharmacology

authors： Allegaert K,Anderson BJ,Cossey V,Holford NH

更新日期：2006-01-01 00:00:00

abstract：AIMS:Paracetamol-containing combination analgesics are widely prescribed but the use of paracetamol/dextropropoxyphene (co-proxamol) is particularly controversial. We aim to examine the prescribing patterns of the paracetamol-containing analgesics in Ireland. METHODS:A national primary care prescribing database was us...

journal_title：British journal of clinical pharmacology

authors： Usher C,Teeling M,Bennett K,McGowan B,Feely J

更新日期：2005-12-01 00:00:00

abstract：AIMS:Dexloxiglumide is a new CCK(1) receptor antagonist under investigation for treatment of functional gastrointestinal disorders and is metabolized by CYP3A4 and CYP2C9. The objectives of these two separate randomized, two-period, two-treatment crossover studies were to investigate the effects of steady-state ketocon...

journal_title：British journal of clinical pharmacology

authors： Jakate AS,Roy P,Patel A,Abramowitz W,Persiani S,Wangsa J,Kapil R

更新日期：2005-11-01 00:00:00

abstract：AIMS:The study was designed to evaluate the relative bioavailability of diclofenac in plasma, subcutaneous adipose and skeletal muscle tissue after repeated topical administration using MIKA Diclofenac Spray Gel (4%), a novel formulation, and after oral dosing using VOLTAREN 50 mg enteric coated tablets. METHODS:Diclo...

journal_title：British journal of clinical pharmacology

authors： Brunner M,Dehghanyar P,Seigfried B,Martin W,Menke G,Müller M

更新日期：2005-11-01 00:00:00

abstract：AIMS:To develop a population pharmacokinetic model for lopinavir in combination with ritonavir, in which the interaction between both drugs was characterized, and in which relationships between patient characteristics and pharmacokinetics were identified. METHODS:The pharmacokinetics of lopinavir in combination with r...

journal_title：British journal of clinical pharmacology

authors： Crommentuyn KM,Kappelhoff BS,Mulder JW,Mairuhu AT,van Gorp EC,Meenhorst PL,Huitema AD,Beijnen JH

更新日期：2005-10-01 00:00:00

abstract：AIMS:To investigate the extent of concomitant use of analgesic and psychotropic medicines among home-dwelling elderly people aged at least 75 years in Finland. METHODS:This was a population-based study in Finland, performed as part of Kuopio 75 + study focusing on the clinical epidemiology of diseases, medication and ...

journal_title：British journal of clinical pharmacology

authors： Hartikainen S,Mäntyselkä P,Louhivuori-Laako K,Enlund H,Sulkava R

更新日期：2005-09-01 00:00:00